Lambert Eaton Syndrome

What is Lambert Eaton Syndrome

Definition- Lambert Eaton syndrome is a rare autoimmune diseases that affects the mobility of the body.

It is the autoimmune diseases in which immune system attacks its own body cells and specially the neuromuscular tissues leads to difficulty in walking and the other musculoskeletal movements.

The diseases cannot be cured but symptomatic treatment can gives better results.


Causes of Lambert Eaton Syndrome

  • Immune system of the body produces the antibodies for the defense mechanism in body. These antibodies attacks any kind of foreign body that causes any harm to the body.
  • But in this diseases, the antibodies attacks its own body cells and decreases the immunity of the body.
  • In this LES, the body attacks the nerve endings that controls the amount of acetylcholine releases.

  • Acetylcholine is a neurotransmitter that triggers the muscle contraction. Muscles makes the body movements and helps in walking, running standing, jogging, and all other movements.
  • For the release of the neurotransmitter a protein called VGCC is required voltage gated calcium channel to release the acetylcholine.

  • In the lack of this protein release of acetylcholine is reduced hence the muscles does not works in accordance of the movement.

Symptoms of Lambert Eaton Syndrome

  • Progressive weakness in the legs and thigh muscles.
  • Digestive problems
  • Constipation
  • Dryness of mouth
  • Facial muscles paralysis
  • Infections
  • Swallowing and breathing difficulties

Diagnosis of Lambert Eaton Syndrome

  • Diagnosis is based upon the history and the physical examination taken.
  • Blood test- for checking of the antibodies against the vgcc protein.
  • MMT- for muscle power.
  • NCV- nerve conduction velocity testing of nerve fibers that stimulates the nerve muscles.

Treatment of Lambert Eaton Syndrome

  • This condition cannot  be cured only the symptomatic treatment is to be given.
  • Immune boosters to be given in the form of immunoglobulin through intravenous.
  • Plasmapheresis- in which plasma is separated and antibodies are removed and after against inserted into blood.
  • Drugs can be given for relief of muscular pain.
  • Rehabilitative physiotherapy is also works good in strengthening the muscles and supportive treatment in balancing and coordination. 
Prognosis depend upon the immunity system and the treatment available on the onset of diseases.

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